In every hair follicle, a complex interaction between epithelial and mesenchymal cells is crucial for hair growth and retention, with fibroblast cells playing a pivotal role. Epithelial cells form the structural foundation surrounding the follicle, while mesenchymal cells, located at the core, possess the remarkable ability to differentiate into multiple cell types. However, it is the fibroblasts, through the secretion of collagen, that maintain the connective tissue architecture, providing the necessary support to anchor hair follicles securely to the scalp.

As practitioners, you’re well aware that age and other factors diminish fibroblast activity, leading to the weakening of the tissue matrix surrounding hair follicles. The result is less structural integrity, which often manifests in progressive hair thinning and, eventually, permanent hair loss at the follicular level. This decline in fibroblast function is a critical factor in the onset of permanent alopecia.

However, advancements in the field, notably Claire Higgins’ 2013 research, have demonstrated the potential to stimulate the regeneration of hair follicles by processing and reintroducing dermal papilla cells. By leveraging the regenerative capacity of fibroblasts, there is now a viable pathway to not only halt hair loss but to promote new follicle development. This approach opens up exciting possibilities for practitioners to offer cutting-edge, biologically-based treatments that address the underlying cellular deficiencies driving hair loss.

With these insights into fibroblast biology, practitioners are equipped to guide patients through innovative treatments aimed at rebuilding follicular structures and stimulating hair regrowth. By targeting fibroblasts and enhancing their ability to regenerate connective tissue, we can offer more effective and long-lasting solutions for hair rejuvenation.

This knowledge empowers practitioners to offer advanced, fibroblast-centered therapies that support hair regrowth, providing clients with superior outcomes based on the latest regenerative science.

Dermomine is an autologous micrografting kit, which harvests cells from the dermal layer (papilla) of the skin and processes them, so a live culture can be injected into tissue. When targeting hair restoration, Dermomine works by harvesting and processing tissue from the head that is rich in fibroblast cells and other mesenchymal cells, and reintroduces them to the scalp. Due to genetics, autoimmune diseases and age, the body slows down (or stops) production of these cells on the head, making individuals lose hair. Dermomine reverses this effect by reintroducing a healthy colony of fibroblasts and progenitor cells that, when combined with PRP, provides a compelling option for hair restoration