EXOMINE

Autologous, fully injectable platelet-derived exosomes.

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exomine, exosome-rich plasma

Platelet-derived Exosomes

Exomine provides a completely autologous method to harvest platelet-derived exosomes. The kit facilitates the release of billions of vesicles by applying stress to the platelets within PRP through a microlyzer cutting tool and a uniquely designed PRF tube, delivering a final count of 25-30 billion vesicles of exosomes that can be injected into the patient.

The Microlyzer Blade. The 600um Microlyzer has specially designed blades and structure to induce stress on blood cells, leading to the release to billions of vesicles. It also plays a crucial role in the activation of platelet cells. 

Advanced PRF Tube. T-Lab, in collaboration with specialist medical professionals, have developed a patented and uniquely designed "advanced PRF tube" as a result of studies aimed at enhancing vesicle release of blood cells. Its specially grooved design facilitates the release of billions of vesicles and activation of platelet cells. 

THE SCIENCE

Exosomes are tiny particles released from cells, belonging to a broader category called extracellular vesicles (EVs). Initially, scientists thought EVs were simply the cell's way of getting rid of unwanted proteins and waste, much like cellular rubbish bins. However, further research has revealed that these vesicles play a crucial role in cell-to-cell communication, acting as messengers that influence the body's next actions.

Extracellular vesicles come in different sizes, with the largest being apoptotic bodies, which are involved in maintaining homeostasis, such as regulating body temperature.

Exosomes are the smallest type of extracellular vesicle, measuring just 30 to 150 nanometers in width. They carry a variety of biological materials like DNA, RNA, proteins, and lipids, all of which are essential for cell communication and maintenance. Exosomes have been shown to promote myelin formation, support neurite growth, and enhance neuronal survival, making them key players in tissue repair and regeneration. Interestingly, exosomes in the central nervous system also contain proteins that help combat diseases, highlighting their role in maintaining health.

Results of nanosignt NS300 NTA:

FTLA Concentration 7 graph for Experiment: "Striped Tube EV 1-200"

(Measurements were conducted at Yeditepe University Biosidal and R&D Laboratories

Results of nanosignt NS300 NTA:

FTLA Concentration 7 graph for Experiment: "Striped Tube EV 1-200"

(Measurements were conducted at Yeditepe University Biosidal and R&D Laboratories

Results of Flow Cytometry:

  • CD9 (Platelet) 99.6%
  • CD45 (Pan Leukocyte Marker) 0.3%
  • CD41 (Platelet GPIIb, IIb Integrin) 99.4%
  • CD61 (Platelet glycoprotein GPIIIa) 98.6%
  • CD81 (Target for anti-proliferative antigen 1 [TAPA-1]) 98.5%
  • 7 AAD: 98.9%

Immunophenotypic measurements were performed using the Beckman Coulter DxFLEX Flow Cytometry system, and the evaluation was completed with the CytExpert DxFLEX software program. (Measurements were implemented at the Private Deren Laboratory)

Results of Flow Cytometry:

  • CD9 (Platelet) 99.6%
  • CD45 (Pan Leukocyte Marker) 0.3%
  • CD41 (Platelet GPIIb, IIb Integrin) 99.4%
  • CD61 (Platelet glycoprotein GPIIIa) 98.6%
  • CD81 (Target for anti-proliferative antigen 1 [TAPA-1]) 98.5%
  • 7 AAD: 98.9%

Immunophenotypic measurements were performed using the Beckman Coulter DxFLEX Flow Cytometry system, and the evaluation was completed with the CytExpert DxFLEX software program. (Measurements were implemented at the Private Deren Laboratory)

BEFORE AND AFTER

One Treatment of Exomine, 6 months apart

Before After

One treatment of Exomine, 6 months apart

Before After

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