DERMOMINE

Micrografting technology for unparalleled regeneration.

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Autologous Micrografting Technology

Dermomine harvests skin cells rich with fibroblasts and mesenchymal stem cells, and processes them for an autologous regenerative solution. Dermomine uses progenitor fibroblast cells for rejuvenation, which provide:

  • Collagen
  • Hyaluronic Acid
  • Extracellular Matrix Synthesis
  • Epithelial Differentiation
  • Secretion of growth factors and cytokines
  • Elasticity

STEP 1

Sterilise the skin behind the ear (or near the groin) before applying a local anaesthesia. Take a minimum of three 2mm skin grafts from the area.

STEP 2

Mix the grafts with either PRP or a saline solution. It is then passed through a 600um Microlyzer 51 times.

STEP 3

Pass the solution through the 150um Microlyzer once prior to injection - this filters out fibrotic and unwanted tissues.

THE SCIENCE

The skin is a complex organ composed of various cells and glands, each performing distinct functions. It is intricately held together by proteins and nourished with oxygen and nutrients. Because of this complexity, merely transferring skin tissue from one part of the body to another does not naturally support effective regenerative processes.

Successful skin regeneration requires more than just tissue placement; it involves a comprehensive understanding of the skin's intricate structure and the biological processes that sustain its function.

When harvesting a micrograft, we collect a tissue sample rich in diverse cell types. Key components of this graft include:

  • Dermal Fibroblasts: These cells are crucial for the structural integrity and repair of the skin. They produce collagen and other extracellular matrix proteins that support skin regeneration.
  • Mesenchymal Stem Cells (MSCs): These progenitor cells have a vital role in skin regeneration. They can differentiate into various cell types and replace damaged cells or transform into cells needed in the affected area.

In essence, the inclusion of dermal fibroblasts and mesenchymal stem cells in micrografts enhances their regenerative potential, making them effective for repairing and rejuvenating the skin.

Total Cell Count -

Nucleated Cell Number = 8ml x 1.68 x 10^6

= 13.4 x 10^6

End Product: volume of 8ml with a 97.2% viability

Total Cell Count -

Nucleated Cell Number = 8ml x 1.68 x 10^6

= 13.4 x 10^6

End Product: volume of 8ml with a 97.2% viability

Essential markers for follicle regeneration:

CD200+: Hair Follicle Epithelial Stem Cells

CD44+: Hair Follicle-Derived Mesenchymal Stem Cells

CK15+: Bulge Area Cells

Essential markers for follicle regeneration:

CD200+: Hair Follicle Epithelial Stem Cells

CD44+: Hair Follicle-Derived Mesenchymal Stem Cells

CK15+: Bulge Area Cells

BEFORE AND AFTER

One Treatment of Dermomine

Before After

One treatment of Dermomine, 3 months apart.

Before After

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