Hair Regrowth

Regenerative Medicine for Hair Regrowth

Regenerative medicine is transforming hair restoration by tapping into the body’s natural healing processes to stimulate new hair growth. Unlike traditional treatments that mainly slow hair loss, regenerative approaches focus on repairing and regenerating hair follicles, resulting in thicker and healthier hair.

PRP & PRF

PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) are widely recognized for their effectiveness in combating hair loss. Moreover, extensive research and empirical evidence have shown that these treatments can significantly reverse the signs of hair thinning. When activated, the platelets in PRP release a variety of growth factors and cytokines from their alpha granules, including platelet-derived endothelial growth factor (PDGF), transforming growth factor β (TGF-β), fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), and glial cell line–derived neurotrophic factor (GDNF). Together, these elements play a crucial role in stimulating hair growth by promoting cell proliferation, differentiation, and the formation of new blood vessels (angiogenesis).

PRP and PRF may be effective in treating several hair loss conditions:

  • Androgenetic Alopecia: Also known as male or female pattern hair loss, this type of hair loss follows a well-defined pattern, often beginning at the temples. Notably, meta-analyses of PRP for this condition have shown a significant increase in both hair count and hair thickness.

  • Alopecia Areata: This common autoimmune disorder causes nonscarring hair loss in both males and females at any age. Since PRP has anti-inflammatory properties, it has been suggested as a potential treatment for alopecia areata. In fact, in a study involving 45 patients with AA, PRP treatments led to significantly increased hair growth and higher levels of Ki-67 (a marker of cell proliferation) compared to placebo injections.

  • Hair Transplantation: Furthermore, several studies have demonstrated the benefits of using PRP in conjunction with hair transplants. In three studies, patients who received PRP showed a greater follicular unit density compared to those who received saline or no injection, indicating that PRP is highly effective in supporting hair regrowth after transplantation.

Photos below: All patients treated with T-Lab PRF (PRX) tubes. 

Exomine

While PRP and PRF have demonstrated significant effectiveness in hair regrowth, ongoing advancements in regenerative medicine continue to explore new frontiers. Among these emerging therapies, exosomes are gaining attention for their potential to further enhance hair restoration.

The reason for this is that exosomes play a crucial role in cell-to-cell communication, transporting key cellular components such as microRNAs, mRNAs, DNA, lipids, metabolites, and cell-surface proteins (Caliskan et al.) that enable the body to communicate with itself and generate self-restoration.

Although scientific research is still in its infancy, exosomes exhibit significant potential in the field of hair regrowth. For instance, studies conducted using animal models and at the cellular level have demonstrated that exosomes effectively promote hair growth. Consequently, researchers suggest that exosome therapy is emerging as a promising option for the treatment of alopecia.

Dermomine

Dermomine is maybe the stand out product, when considering its effectiveness in promoting hair regrowth, as illustrated by the photos below. Dermomine works by harvesting and processing tissue (taken from the head) that is rich in fibroblast cells and reintroduces them at the location of hair follicles. This is highly effective, because fibroblasts act like anchors for hair, forming a structure that holds a hair follicle in place. Due to genetics, autoimmune diseases and age, the body slows down (or stops) its production of these cells on the head, making individuals lose hair. Dermomine reverses this affect by reintroducing a healthy colony of fibroblasts that, when combined with PRP, provides a compelling option for hair restoration.

 

CD34

CD44

CD45

CD200

CYTOKERATIN 15

VIABILITY 

DERMOMINE SAMPLE

0.2%

67.2%

5.9%

68.0%

52%

94,8%

When examining hair regrowth and regeneration, several key markers are crucial for the process. These include:

  • CD200+: Hair Follicle Epithelial Stem Cells: These cells are involved in managing autoimmunity within hair follicles.
  • CD44+: Hair Follicle-Derived Mesenchymal Stem Cells: These cells are vital for stimulating hair growth.
  • CK15+: Bulge Area Cells: These cells help regulate the early stages of keratinocyte differentiation, influencing whether a cell develops into hair or skin.
  • CD34: This marker is found on Hematopoietic Stem Cells (HSCs) located in the outer root sheath of the anagen hair follicle.
  • Cytokeratin (CK15): CK15 may play a role in early keratinocyte differentiation, affecting whether a cell becomes epidermal or hair-like (reference: Ossama Abbas).

These markers demonstrate how Dermomine has all the components needed to not only stimulate hair regrowth, but deal with the root cause of hair loss. When combined with PRP or PRF, clinicians will be dealing with the root cause of the problem by introducing cultures of fibroblasts, whilst securing their growth and proliferation with growth factors inherent to PRP treatments. While PRP and PRF are known for their effectiveness, a single session of a combined Dermomine treatment might achieve what would take 3-4 sessions of PRP or PRF alone.

 Below: one treatment of Dermomine, 2 months apart. 

 

 

Lipomine

SVF

References: 

Abbas, O., Richards, J., Yaar, R. et al. Stem cell markers (cytokeratin 15, cytokeratin 19 and p63) in in situ and invasive cutaneous epithelial lesions. Mod Pathol 24, 90–97 (2011). https://doi.org/10.1038/modpathol.2010.180

Xing YZ, Guo HY, Xiang F, Li YH. Recent progress in hair follicle stem cell markers and their regulatory roles. World J Stem Cells. 2024 Feb 26;16(2):126-136. doi: 10.4252/wjsc.v16.i2.126. PMID: 38455104; PMCID: PMC10915958.

Paichitrojjana A, Paichitrojjana A. Platelet Rich Plasma and Its Use in Hair Regrowth: A Review. Drug Des Devel Ther. 2022 Mar 10;16:635-645. doi: 10.2147/DDDT.S356858. PMID: 35300222; PMCID: PMC8922312

Cheng M, Ma C, Chen HD, Wu Y, Xu XG. The Roles of Exosomes in Regulating Hair Follicle Growth. Clin Cosmet Investig Dermatol. 2024 Jul 5;17:1603-1612. doi: 10.2147/CCID.S465963. PMID: 38984321; PMCID: PMC11232880.

Contact form